1: tert-butyl pent-4-enoate With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; Michael addition; 0.5 h; Inert atmosphere; 2: 1,3-diphenyl-2-(phenylmethylene)-1,3-ropanedione in tetrahydrofuran; hexane T=-78 - 20°C; Michael addition; Inert atmosphere; optical yield given as percent dediastereoselective reaction;

piperidine in ethanol 2.5 h; Ambient temperature;

piperidine; acetic acid in benzene Knoevenagel condensation; 2 h; Heating;

pyrrolidine in ethanol 240 h; Heating;

acetic acid in acetonitrile 40 h; Heating;

acetic acid in ethanol 4 h; Heating;

in ethanol Product distribution;

formic acid; triethylamine T=145 - 150°C;

sodium tetrahydroborate; cerium(III) chloride heptahydrate in methanol; dichloromethane T=-78 - 20°C; Luche Cerium Reduction; 12 h;