N-Boc-(4’-氯苯基)甘氨酸合成路线 （共 5 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=20°C; 15 h; 2: With hydrogenchloride in water pH=1; Cooling;
参考文献
CHIESI FARMACEUTICI S.p.A.
Patent: US2012/134934 A1, 2012 ;
Location in patent: Page/Page column 28 ;
反应条件
1: N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-4-chlorobenzylamine With TMS-SnBu3; cesium fluoride in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: carbon dioxide in N,N-dimethyl-formamide T=100°C; P=7500.75 Torr; 3 h; Autoclave; 3: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide pH=2; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 6 p. 1393 - 1396
反应条件
1: With cesium fluoride in N,N-dimethyl-formamide T=100°C; P=7500.75 Torr; 3 h; Autoclave; 2: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide T=0°C; pH=2; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 77, # 5 p. 2159 - 2168
反应条件
1.1: formic acid / methanol; water / 60 h / 20 °C / Inert atmosphere 2.1: TMS-SnBu3; cesium fluoride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere 2.2: 3 h / 100 °C / 7500.75 Torr / Autoclave 2.3: pH 2 / Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 6 p. 1393 - 1396
反应条件
1.1: formic acid / methanol; water / 60 h / 20 °C / Inert atmosphere 2.1: TMS-SnBu3; cesium fluoride / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere 2.2: 3 h / 100 °C / 7500.75 Torr / Autoclave 2.3: pH 2 / Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 6 p. 1393 - 1396
