4,6-二氯吲哚-2-甲酸乙酯合成路线 （共 12 条）
反应条件
1: N-methyl-N-formyl-aniline With trichlorophosphate T=20°C; Inert atmosphere; 2: 4,6-dichloro-indole-2-carboxylic acid,ethyl ester in 1,2-dichloro-ethane Vilsmeier formylation; 8 h; Inert atmosphereReflux;
参考文献
Bauman; Piel; Hoehnemann; Krauss; Jansen; Solbach; Dannhardt; Roesch
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 10 p. 645 - 656
反应条件
sodium acetate; trichlorophosphate in N-methyl-acetamide; anhydrous dichloroethane
参考文献
Merrell Pharmaceuticals Inc.
Patent: US5519048 A1, 1996 ;
US 5519048 A
