1: acetonitrile / 20 °C
2: 320 mg / KI; chlorotrimethylsilane / 16 h / 25 °C
View Scheme
参考文献
Kelley, James L.; Kelsey, John E.; Hall, William R.; Krochmal, Mark P.; Schaeffer, Howard J.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 753 - 756
1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate; phosphoric acid / water / 22 h / 20 - 100 °C / Industry scale
2.1: zinc dibromide / 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h
2.2: 35 °C / Industry scale
3.1: diisopropylamine / isopropyl alcohol; toluene / 6.4 h / 10 - 90 °C / Industry scale
4.1: ethanol; water / 70 °C / Industry scale
View Scheme
