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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
碘苷
合成路线
（共 84 条）
54-42-2
碘苷
→
反应条件
647852-39-9
反应条件
1: 96 percent / Et3N; CuI / Pd(PPh3)4 / dimethylformamide / 22 - 24 °C 2: 78 percent / DMAP / pyridine / 6.5 h / 22 - 24 °C 3: 68 percent / LiOH*H2O / methanol; tetrahydrofuran / 1.33 h / 22 - 24 °C 4: pyridine / 2.5 h / 22 - 24 °C 5: 0.057 g / CF3CO2H / CH2Cl2 / 0.5 h / 22 - 24 °C View Scheme
参考文献
Held, Heike A.; Roychowdhury, Abhijit; Benner, Steven A.
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 4 p. 391 - 404
6783-05-7
反式-BETA-苯乙烯硼酸
+
54-42-2
碘苷
→
反应条件
72045-17-1
反应条件
Pd(PPh2)(m-C6H4SO3Na)*(H2O)4; sodium carbonate in methanol; water T=80°C; 3 h;
参考文献
Casalnuovo, Albert L.; Calabrese, Joseph C.
Journal of the American Chemical Society, 1990 , vol. 112, # 11 p. 4324 - 4330
292638-84-7
+
54-42-2
碘苷
→
反应条件
72045-17-1
反应条件
palladium diacetate; triethylamine in water; acetonitrile T=80°C; Heck reaction; Inert atmosphere;
参考文献
Cho, Joon Hyung; Shaughnessy, Kevin H.
Synlett, 2011 , # 20 art. no. S07411ST, p. 2963 - 2966
54-42-2
碘苷
+
88154-01-2
→
反应条件
反应条件
tetrabutyl ammonium fluoride; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran T=60°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Matsuhashi, Hayao; Hatanaka, Yasuo; Kuroboshi, Manabu; Hiyama, Tamejiro
Heterocycles, 1996 , vol. 42, # 1 p. 375 - 384
54-42-2
碘苷
+
98-80-6
苯硼酸
→
反应条件
76756-28-0
反应条件
Na2[PdCl4]; potassium hydroxide in water T=100°C; Suzuki-Miyaura Coupling; 0.5 h; Inert atmosphereGreen chemistry; ConcentrationTimeReagent/catalyst;
参考文献
Gallagher-Duval, Shawn; Herve, Gwenaelle; Sartori, Guillaume; Enderlin, Gerald; Len, Christophe
New Journal of Chemistry, 2013 , vol. 37, # 7 p. 1989 - 1995
54-42-2
碘苷
→
反应条件
76756-28-0
反应条件
1: 89 percent / pyridine, EtN-iPr2 / 3 h / Ambient temperature 2: Pd(Ph3P)4 / hexamethylphosphoric acid triamide / 72 h / 60 °C 3: MeONa / methanol View Scheme
参考文献
Bigge, Christopher F.; Mertes, Mathias P.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 1994 - 1997
54-42-2
碘苷
+
934-56-5
三甲基(苯基)锡
→
反应条件
76756-28-0
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 24 h; Heating;
参考文献
Hassan, Mohamed Ezeldin
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 9 p. 1944 - 1948
54-42-2
碘苷
+
536-74-3
苯乙炔
→
反应条件
77887-20-8
2'-脱氧-5-(苯基乙炔基)-尿苷
反应条件
copper(l) iodide; palladium diacetate; triethylamine; TXPTS in water; acetonitrile T=65°C; Sonogashira coupling; 0.5 h; Inert atmosphere;
参考文献
Hyung Cho, Joon; Prickett, Caitlin D.; Shaughnessy, Kevin H.
European Journal of Organic Chemistry, 2010 , # 19 p. 3678 - 3683
54-42-2
碘苷
→
反应条件
77887-20-8
2'-脱氧-5-(苯基乙炔基)-尿苷
反应条件
1: 89 percent / pyridine / 24 h / 20 °C 2: 90 percent / Et3N / Pd(PPh3)4; CuI / dimethylformamide / 24 h / 20 °C 3: 86 percent / aq. NaOH / pyridine; ethanol / 4 °C View Scheme
参考文献
Hudson, Robert H. E.; Ghorbani-Choghamarani, Arash
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 12 p. 1845 - 1848
54-42-2
碘苷
→
反应条件
869355-24-8
反应条件
1: Bis(triphenylphosphine)palladium(II) / 1,4-dioxane 2: sodium hydroxide / water 3: diisopropyl-carbodiimide / N,N-dimethyl-formamide / 4 h / 25 °C View Scheme
参考文献
RIKEN; Okamoto, Akimitsu; Ikeda, Shuji
Patent: US2013/289263 A1, 2013 ;
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