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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
碘苷
合成路线
（共 84 条）
54-42-2
碘苷
+
796875-93-9
→
反应条件
796875-91-7
反应条件
copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=20°C; Sonogashira reaction; 6 h;
参考文献
Saito, Yoshio; Miyauchi, Yohei; Okamoto, Akimitsu; Saito, Isao
Tetrahedron Letters, 2004 , vol. 45, # 42 p. 7827 - 7831
871-84-1
1,7-辛二炔
+
54-42-2
碘苷
→
反应条件
909398-18-1
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine in N,N-dimethyl-formamide T=20°C;
参考文献
Seela, Frank; Sirivolu, Venkata Ramana
Helvetica Chimica Acta, 2007 , vol. 90, # 3 p. 535 - 552
54-42-2
碘苷
→
反应条件
909398-18-1
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1H-imidazole; pyridine 2: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme
参考文献
baseclick GmbH
Patent: EP2089343 B1, 2011 ;
54-42-2
碘苷
→
反应条件
96141-37-6
3'-O-苄基-2'-脱氧-5-三氟甲基尿苷
反应条件
1: 67 percent / pyridine / 0.33 h / 100 °C 2: 73 percent / sodium hydride (60 percent) / tetrahydrofuran / 1.5 h / Ambient temperature 3: 1.) pyridine, DMF, copper powder, 4-dimethylaminopyridine / 1.) < -70 to 115 deg C; sealed tube, 2.) 8 h, 60 deg C; sealed tube was opened 4: methanolic HCl (2 percent) / 2 h / Ambient temperature View Scheme
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
108-05-4
醋酸乙烯酯
+
54-42-2
碘苷
→
反应条件
55520-67-7
5-乙烯基-2'-脱氧尿苷
反应条件
tributyl-amine; palladium diacetate in N,N-dimethyl-formamide T=80°C; Heck reaction; 0.333333 h; Microwave irradiation;
参考文献
Ogino, Masayuki; Taya, Yuuta; Fujimoto, Kenzo
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 15 p. 3163 - 3167
54-42-2
碘苷
→
反应条件
55520-67-7
5-乙烯基-2'-脱氧尿苷
反应条件
1: 89 percent / pyridine, EtN-iPr2 / 3 h / Ambient temperature 2: Pd(Ph3P)4 / hexamethylphosphoric acid triamide / 60 °C 3: MeONa / methanol View Scheme
参考文献
Herdewijn; Kerremans; Wigerinck; Vandendriessche; Van Aerschot
Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4397 - 4400
54-42-2
碘苷
+
7486-35-3
三丁基乙烯基锡
→
反应条件
55520-67-7
5-乙烯基-2'-脱氧尿苷
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 24 h; Heating;
参考文献
Hassan, Mohamed Ezeldin
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 9 p. 1944 - 1948
772-38-3
4-叔丁基苯基乙炔
+
54-42-2
碘苷
→
反应条件
596107-17-4
反应条件
copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=40°C; Sonogashira coupling; 25 h;
参考文献
Meneni, Srinivasarao; Ott, Ingo; Sergeant, Craig D.; Sniady, Adam; Gust, Ronald; Dembinski, Roman
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 8 p. 3082 - 3088
54-42-2
碘苷
→
反应条件
596107-17-4
反应条件
1: 81 percent / DIPEA; Pd(Ph3P)4; CuI / dimethylformamide / 20 °C 2: 75 percent / aq. NH3 / methanol / 20 °C 3: 63 percent / Et3N; Pd(Ph3P)4; CuI / dimethylformamide / 15 h / 20 °C View Scheme
参考文献
Luoni, Giovanna; McGuigan, Christopher; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3791 - 3796
54-42-2
碘苷
→
反应条件
644962-74-3
1-{2-脱氧-5-O-[(2,3-二甲氧基苯基)(二苯基)甲基]呋喃戊糖基}-5-(1-丙炔-1-基)-2,4(1H,3H)-嘧啶二酮
反应条件
1: NEt3 / tetrahydrofuran 2: NEt3; CuI / Pd(PPh3)4 / acetone View Scheme
参考文献
Berry, David A.; Jung, Kee-Yong; Wise, Dean S.; Sercel, Anthony D.; Pearson, William H.; Mackie, Hugh; Randolph, John B.; Somers, Robert L.
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2457 - 2461
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