4-氟-1-(4-氟-2-甲氧基-苯基)-2-甲氧基苯合成路线 （共 4 条）
反应条件
dichloro bis(acetonitrile) palladium(II); triphenyl-arsane; silver(l) oxide in tetrahydrofuran
T=65°C; Suzuki Coupling; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Barbosa, Luiz C. A.; Maltha, Celia R. A.; Lage, Mateus R.; Barcelos, Rosimeire C.; Dona, Alice; Carneiro, Jose W. M.; Forlani, Giuseppe
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 42 p. 10555 - 10563
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in tetrahydrofuran; water
43 h; Inert atmosphereReflux;
参考文献
Aikawa, Kohsuke; Miyazaki, Yoshitaka; Mikami, Koichi
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 2 p. 201 - 208
反应条件
copper bronze
T=200°C; 0.666667 h;
参考文献
Bloomfield, Colin; Manglik, Ajay K.; Moodie, Roy B.; Schofield, Kenneth; Tobin, Geoffrey D.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , p. 75 - 82
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -50 °C / Inert atmosphere
1.3: 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 43 h / Inert atmosphere; Reflux
View Scheme
参考文献
Aikawa, Kohsuke; Miyazaki, Yoshitaka; Mikami, Koichi
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 2 p. 201 - 208
