5-甲基-1,3-二氢苯并咪唑-2-酮合成路线 （共 34 条）
反应条件
in tetrahydrofuran T=20°C;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US8138168 B1, 2012 ;
Location in patent: Page/Page column 477-478 ;
US 8138168 B1
反应条件
TBA2[WO4] in 1-methyl-pyrrolidin-2-one T=139.84°C; P=15001.5 Torr; 24 h; Autoclave;
参考文献
Kimura, Toshihiro; Kamata, Keigo; Mizuno, Noritaka
Angewandte Chemie - International Edition, 2012 , vol. 51, # 27 p. 6700 - 6703
反应条件
selenium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine in toluene T=150°C; P=22800 Torr; 4 h;
参考文献
Wang, Xiaofang; Ling, Gang; Xue, Yan; Lu, Shiwei
European Journal of Organic Chemistry, 2005 , # 8 p. 1675 - 1679
反应条件
sodium hydroxide in methanol T=40°C; 4 h;
参考文献
Porzelle, Achim; Woodrow, Michael D.; Tomkinson, Nicholas C.O.
Organic Letters, 2010 , vol. 12, # 7 p. 1492 - 1495
反应条件
sodium hydroxide in methanol T=40°C; 4 h;
参考文献
Porzelle, Achim; Woodrow, Michael D.; Tomkinson, Nicholas C.O.
Organic Letters, 2010 , vol. 12, # 7 p. 1492 - 1495
反应条件
sodium hydroxide in methanol T=40°C; 4 h;
参考文献
Porzelle, Achim; Woodrow, Michael D.; Tomkinson, Nicholas C.O.
Organic Letters, 2010 , vol. 12, # 7 p. 1492 - 1495
参考文献
CRYSOPTIX K.K.
Patent: WO2009/109782 A2, 2009 ;
Location in patent: Page/Page column 14 ;
反应条件
triethylamine in 1,4-dioxane 1.5 h; Heating / reflux;
参考文献
EP1445249 A1, ;
Page 129 ;
反应条件
1: 75 percent / cc. sulphuric acid, ZnCl2 / acetic acid 2: 67 percent / aq. sulphuric acid / acetic acid / 2.5 h / 100 °C 3: 83 percent / HCl / Heating 4: 46 percent / sodium ethoxide / ethanol; dimethylformamide / 2 h 5: 85 percent / cc. HCl / 4 h 6: 72 percent / aq.NH3 7: 39 percent / 750 °C / 0.05 - 0.07 Torr View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 681 - 690
反应条件
in N,N-dimethyl acetamide; diethylene glycol 0.05 h; Irradiation;
参考文献
Khajavi, Mohammad S.; Hajihadi, Mostafa; Naderi, Reza
Journal of Chemical Research - Part S, 1996 , # 2 p. 92 - 93
