4-氨基-3,5-二碘苯甲酸乙酯合成路线 （共 7 条）
反应条件
potassium hydroxide 1 h; Heating;
参考文献
Hirschfeld; Buschauer; Elz; Schunack; Ruat; Traiffort; Schwartz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2231 - 2238
反应条件
iodine cloride in dichloromethane
1 h; Heating;
参考文献
Hirschfeld; Buschauer; Elz; Schunack; Ruat; Traiffort; Schwartz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2231 - 2238
反应条件
iodine cloride
Heating;
参考文献
Charrier, Nicolas; Demont, Emmanuel; Dunsdon, Rachel; Maile, Graham; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Theobald, Pam; Vesey, David; Walter, Daryl
Synlett, 2005 , # 20 art. no. D23305ST, p. 3071 - 3074
参考文献
Wheeler; Liddle
American Chemical Journal, 1909 , vol. 42, p. 457
参考文献
Frejka; Pirkl
Cesko-Slovenska Farmacie, 1952 , vol. 1, p. 309,312
Chem.Abstr., 1952 , p. 11583
反应条件
1.1: NaH / dimethylformamide; various solvent(s) / 0.17 h / 0 °C
1.2: dimethylformamide; various solvent(s) / 0.5 h / 0 - 20 °C
2.1: 6.3 g / HCO2Na; Na2CO3; TBACl / Pd(OAc)2 / dimethylformamide / 0.5 h / 80 °C
View Scheme
参考文献
Charrier, Nicolas; Demont, Emmanuel; Dunsdon, Rachel; Maile, Graham; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Theobald, Pam; Vesey, David; Walter, Daryl
Synlett, 2005 , # 20 art. no. D23305ST, p. 3071 - 3074
反应条件
sodium hydride in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 0.783333 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/94430 A1, 2004 ;
Location in patent: Page 25 ;
WO 2004/094430 A1
