1: 1) 2 N K2CO3 / 2) ether, 20 deg C, 24 h, 3) reflux, 2 h, 4) hydrolysis 2: ethanol / 0.67 h / Heating 3: ion exchanger (Lewatit MP 600) / H2O; methanol 4: 73 percent / 400 °C View Scheme

in dichloromethane 16 h; Ambient temperature;

hydrogenchloride in ethanol Mannich reaction; Heating;

sodium acetate T=95°C; 0.25 h;