4-甲基-2-(4-甲基苯基)-1,3-噻唑-5-羧酸合成路线 （共 5 条）
反应条件
1: With water; sodium hydroxide T=130°C; 0.0833333 h; 2: With hydrogenchloride in water pH=3;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 156 ;
WO 2010/142801 A1
反应条件
1: SeO2 / aq. acetic acid / 2 h / Heating 2: 40percent aq. KOH / 24 h / Ambient temperature 3: K2Cr2O7, glacial acetic acid / 1 h View Scheme
参考文献
Archiv der Pharmazie, , vol. 314, # 9 p. 744 - 750
反应条件
2: KOH / ethanol View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , p. 1195 - 1205
反应条件
potassium dichromate; acetic acid 1 h;
参考文献
Archiv der Pharmazie, , vol. 314, # 9 p. 744 - 750
反应条件
1: 40percent aq. KOH / 24 h / Ambient temperature 2: K2Cr2O7, glacial acetic acid / 1 h View Scheme
参考文献
Archiv der Pharmazie, , vol. 314, # 9 p. 744 - 750
