2-(4-氯苯基)-4-甲基-1,3-噻唑-5-羧酸合成路线 (共 5 条)
反应条件
sodium hydroxide in ethanol; water T=85°C; 1.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 4 p. 685 - 695
反应条件
lithium hydroxide; water in methanol; ethanol 1 h; RefluxInert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 15 p. 4660 - 4671
反应条件
1: ethanol / 24 h / Heating 2: 92 percent / NaOH / ethanol; H2O / 1.5 h / 85 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 4 p. 685 - 695
反应条件
thionyl chloride
Heating;
参考文献
Mayhoub, Abdelrahman S.; Khaliq, Mansoora; Kuhn, Richard J.; Cushman, Mark
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1704 - 1714
反应条件
1: SOCl2 / Heating
2: diethyl ether; benzene
3: aq. HBr / ethanol / 0.25 h / Heating
View Scheme
参考文献
Csavassy,G.; Gyoerfi,Z.A.
Justus Liebigs Annalen der Chemie, 1974 , p. 1195 - 1205