1: 17.01 g / LiAlH4 / diethyl ether / a) 10 deg C, 1 h, b) RT, 1 h 2: 36.05 g / pyridine / Ambient temperature 3: 6.01 g / NaBr / dimethylsulfoxide / 144 h / Ambient temperature View Scheme
参考文献
Takatsuto, Suguru; Watanabe, Tsuyoshi; Gotoh, Chiharu; Kuriyama, Hiroki; Noguchi, Takahiro; Fujioka, Shozo
Journal of Chemical Research, Miniprint, 1998 , # 4 p. 844 - 852
1: 3-Methyl-butanoic acid ethyl ester With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h; Inert atmosphereSchlenk technique;
2: methyl iodide in tetrahydrofuran
T=-78 - 20°C; 2 h; Inert atmosphereSchlenk technique;
参考文献
Nitsch, Dominik; Huber, Stefan M.; Poethig, Alexander; Narayanan, Arjun; Olah, George A.; Prakash, G. K. Surya; Bach, Thorsten
Journal of the American Chemical Society, 2014 , vol. 136, # 7 p. 2851 - 2857