5-(3-氟苯基)-呋喃-2-羧酸甲酯合成路线 （共 4 条）
反应条件
lithium hydroxide hydrate in tetrahydrofuran; methanol; water 24 h; Inert atmosphere;
参考文献
Ballard, T. Eric; Wang, Xia; Olekhnovich, Igor; Koerner, Taylor; Seymour, Craig; Salamoun, Joseph; Warthan, Michelle; Hoffman, Paul S.; Macdonald, Timothy L.
ChemMedChem, 2011 , vol. 6, # 2 p. 362 - 377
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane
T=90°C; Suzuki-Miyaura cross coupling; Inert atmosphere;
参考文献
Ballard, T. Eric; Wang, Xia; Olekhnovich, Igor; Koerner, Taylor; Seymour, Craig; Salamoun, Joseph; Warthan, Michelle; Hoffman, Paul S.; Macdonald, Timothy L.
ChemMedChem, 2011 , vol. 6, # 2 p. 362 - 377
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl acetamide
T=130°C; 20 h; Inert atmosphere; regioselective reaction;
参考文献
Fu, Hai Yan; Doucet, Henri
European Journal of Organic Chemistry, 2011 , # 35 p. 7163 - 7173
反应条件
1: 3-fluorophenylamine With hydrogenchloride; sodium nitrite
2: furan-5alpha-carboxylic acid methyl ester With CuCl2*2H2O in water; acetone
T=0 - 30°C;
参考文献
Gorak; Obushak; Matiichuk; Lytvyn
Russian Journal of Organic Chemistry, 2009 , vol. 45, # 4 p. 541 - 550
