4-羟基-3-羟基甲基苯甲醛合成路线 （共 7 条）
反应条件
calcium carbonate in tetrahydrofuran
T=20°C; 13 h;
参考文献
Buchanan, David J.; Dixon, Darren J.; Looker, Brian E.
Synlett, 2005 , # 12 art. no. D12405ST, p. 1948 - 1950
反应条件
hydrogenchloride in water; acetonitrile
Heating;
参考文献
Gisch; Balzarini; Meier
Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 6-7 p. 861 - 864
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 81 percent / HCl / acetonitrile; H2O / Heating
View Scheme
参考文献
Gisch, Nicolas; Balzarini, Jan; Meier, Chris
Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1658 - 1667
反应条件
1.1: 95 percent / p-toluenesulfonic acid monohydrate; Na2SO4 / acetone / 72 h / 40 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C
2.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 81 percent / HCl / acetonitrile; H2O / Heating
View Scheme
参考文献
Gisch, Nicolas; Balzarini, Jan; Meier, Chris
Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1658 - 1667
反应条件
1.1: 89 percent / LiAlH4 / tetrahydrofuran / 3 h
2.1: 95 percent / p-toluenesulfonic acid monohydrate; Na2SO4 / acetone / 72 h / 40 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C
3.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C
4.1: 81 percent / HCl / acetonitrile; H2O / Heating
View Scheme
参考文献
Gisch, Nicolas; Balzarini, Jan; Meier, Chris
Journal of Medicinal Chemistry, 2007 , vol. 50, # 7 p. 1658 - 1667
反应条件
1: 56 percent / aq. HCl / 3.5 h / 65 °C
2: 87 percent / aq. CaCO3 / tetrahydrofuran / 13 h / 20 °C
View Scheme
参考文献
Buchanan, David J.; Dixon, Darren J.; Looker, Brian E.
Synlett, 2005 , # 12 art. no. D12405ST, p. 1948 - 1950
反应条件
toluene-4-sulfonic acid in acetone
参考文献
Guo, Zong-Liang; Deng, Yan-Qiu; Zhong, Shi; Lu, Gui
Tetrahedron Asymmetry, 2011 , vol. 22, # 13 p. 1395 - 1399
