(4-氯苯基)(哌嗪-1-基)甲酮合成路线 （共 11 条）
反应条件
1: With hydrogenchloride in 1,4-dioxane; dichloromethane
T=20°C; 4 h;
2: With sodium hydroxide in water
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/71875 A1, 2006 ;
Location in patent: Page/Page column 78 ;
WO 2006/071875 A1
反应条件
4-methyl-morpholine; 2-chloro-4,6-dimethoxy-[1,3,5]triazine in dichloromethane
T=20°C; 0.166667 h;
参考文献
Bandgar; Pandit
Tetrahedron Letters, 2003 , vol. 44, # 19 p. 3855 - 3858
反应条件
sodium hydroxide in water
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/71958 A1, 2006 ;
Location in patent: Page/Page column 117 ;
WO 2006/071958 A1
参考文献
Bali, Alka; Reddy, A. C. Dinesh Kumar
Medicinal Chemistry Research, 2013 , vol. 22, # 1 p. 382 - 391
反应条件
1: triethylamine / diethyl ether
2: water; dimethyl sulfoxide / 25 °C
View Scheme
参考文献
Im, Li-Ra; Jeon, Sang-Eun; Um, Ik-Hwan
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 4 p. 1153 - 1157
反应条件
1: SOCl2 / Heating
2: AcOH / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Mu, Li; Feng, Si-Shen; Go, Mei Lin
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 6 p. 808 - 816
反应条件
potassium chloride in ethanol
T=25°C; pH=9.71; Kinetics; Further Variations:pH-valuesconcentrations;
参考文献
Castro, Enrique A.; Bessolo, Jorge; Aguayo, Raul; Santos, Jose G.
Journal of Organic Chemistry, 2003 , vol. 68, # 21 p. 8157 - 8161
反应条件
hydrogenchloride in dimethyl sulfoxide; acetonitrile
T=25°C; Substitution; Kinetics;
参考文献
Um, Ik-Hwan; Min, Ji-Sook; Ahn, Jung-Ae; Hahn, Hyun-Joo
Journal of Organic Chemistry, 2000 , vol. 65, # 18 p. 5659 - 5663
反应条件
potassium chloride in ethanol; water
T=25°C; pH=9.41; Kinetics; Further Variations:pH-values;
参考文献
Castro, Enrique A.; Aguayo, Raul; Bessolo, Jorge; Santos, Jose G.
Journal of Organic Chemistry, 2005 , vol. 70, # 19 p. 7788 - 7791
反应条件
potassium chloride in ethanol; water
T=25°C; pH=5.37; Kinetics; Further Variations:pH-values;
参考文献
Castro, Enrique A.; Aguayo, Raul; Bessolo, Jorge; Santos, Jose G.
Journal of Organic Chemistry, 2005 , vol. 70, # 19 p. 7788 - 7791
