6-氨基-1-异丁基-3-甲基-5-亚硝基尿嘧啶合成路线 （共 9 条）
反应条件
acetic acid; sodium nitrite in water 2 h; Ambient temperature;
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 8 p. 653 - 658
反应条件
1: 1.) acetic anhydride, 2.) 10percent aq. NaOH / 1.) 70 deg C, 2 h, 2.) from 20 to 70 deg C, 1 h 2: NaNO2, AcOH / H2O / 2 h / Ambient temperature View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 8 p. 653 - 658
反应条件
1: 94 percent / H2 / Raney-NiW-2 / methanol / 4 h / 5320 Torr 2: 87 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h 3: 89 percent / 12N NaOH / H2O / 2 h / 100 °C 4: 83 percent / 48percent HBr, HBr (gas) / 20 h / Heating 5: 72 percent / methanol / Heating View Scheme
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
反应条件
1: 94 percent / H2 / Raney-NiW-2 / methanol / 4 h / 5320 Torr 2: 91 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h 3: 69 percent / 12N NaOH / H2O / 2 h / 100 °C View Scheme
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
反应条件
1: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C 2: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min 3: K2CO3 / dimethylformamide / 20 - 80 °C View Scheme
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
反应条件
1: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C 2: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min View Scheme
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
反应条件
hydrogen; Raney-NiW-2 in methanol
P=5320 Torr; 4 h;
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
反应条件
1: 94 percent / H2 / Raney-NiW-2 / methanol / 4 h / 5320 Torr
2: 87 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h
3: 89 percent / 12N NaOH / H2O / 2 h / 100 °C
4: 83 percent / 48percent HBr, HBr (gas) / 20 h / Heating
5: 72 percent / methanol / 20 h / Heating
View Scheme
参考文献
Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250
反应条件
1: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C
2: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min
View Scheme
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
