4-(4-氟苯甲酰基氨基)苯甲酸合成路线 （共 5 条）
反应条件
1: With methanol; lithium hydroxide; water in tetrahydrofuran
T=20°C; 2 - 3 h;
2: With hydrogenchloride; water
参考文献
Sattigeri, Jitendra A.; Andappan, Murugaiah M.S.; Kishore, Kaushal; Sethi, Sachin; Kandalkar, Sachin Ramesh; Pal, Chanchal Kumar; Mahajan, Dipak C.; Ahmed, Shahadat; Parkale, Santhosh Sadashiv; Srinivasan, T.; Sharma, Lalima; Bansal, Vinay S.; Chugh, Anita; Davis, Joseph Alexanand
Patent: US2008/300251 A1, 2008 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere
2: methanol; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Zheng, Can-Hui; Yang, Hui; Zhang, Meng; Lu, Shi-Hai; Shi, Duo; Wang, Juan; Chen, Xiu-Hua; Ren, Xiao-Hui; Liu, Jia; Lv, Jia-Guo; Zhu, Ju; Zhou, You-Jun
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 39 - 44
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C / Inert atmosphere
2: methanol; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Zheng, Can-Hui; Yang, Hui; Zhang, Meng; Lu, Shi-Hai; Shi, Duo; Wang, Juan; Chen, Xiu-Hua; Ren, Xiao-Hui; Liu, Jia; Lv, Jia-Guo; Zhu, Ju; Zhou, You-Jun
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 39 - 44
反应条件
1: triethylamine / dichloromethane / 12 h / 20 °C
2: sodium hydroxide / water; ethanol / 60 °C
View Scheme
参考文献
Tang, Yan-Bo; Lu, Dianyun; Chen, Zheng; Hu, Chun; Yang, Ying; Tian, Jin-Ying; Ye, Fei; Wu, Li; Zhang, Zhong-Yin; Xiao, Zhiyan
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 8 p. 2313 - 2318
反应条件
sodium hydroxide
2.5 h; Ambient temperature;
参考文献
Leone-Bay, Andrea; Ho, Koc-Kan; Agarwal, Rajesh; Baughman, Robert A.; Chaudhary, Kiran; DeMorin, Frenel; Genoble, Lise; McInnes, Campbell; Lercara, Christine; Milstein, Sam; O'Toole, Doris; Sarubbi, Donald; Variano, Bruce; Paton, Duncan R.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 13 p. 2571 - 2578
