N,N-二甲氨基氯丙烷盐酸盐合成路线 （共 48 条）
反应条件
sodium hydrogencarbonate in ethanol; dichloromethane
参考文献
The United States of America as represented by the Secretary of the Army
Patent: US4659708 A1, 1987 ;
反应条件
1: 60 percent / NaOH / dioxane / 12 h / Heating 2: 70 percent / aq. HCl / Ambient temperature View Scheme
参考文献
Tripathi, R. P.; Singh, V.; Khan, A. R.; Bhaduri, A. P.; Saxena, G.; Chandra, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 9 p. 791 - 795
反应条件
1.1: potassium hydroxide / water / 0 - 5 °C 1.2: 4 h / 100 - 110 °C / Reflux 2.1: tetrahydrofuran / 0.25 h / -5 °C 2.2: 0.5 h / -5 - 20 °C 2.3: pH 2 3.1: sulfuric acid / water / 6 h / 70 °C 4.1: hydrogen bromide / isopropyl alcohol; acetic acid / 1 h / 20 - 70 °C / pH ~ 2 View Scheme
参考文献
SHODHANA LABORATORIES LIMITED
Patent: US2011/92719 A1, 2011 ;
反应条件
1.1: potassium hydroxide / water / 0 - 5 °C 1.2: 4 h / 100 - 110 °C / Reflux 2.1: tetrahydrofuran / 0.25 h / -5 °C 2.2: 0.5 h / -5 - 20 °C 2.3: pH 2 3.1: sulfuric acid / water / 6 h / 70 °C View Scheme
参考文献
SHODHANA LABORATORIES LIMITED
Patent: US2011/92719 A1, 2011 ;
反应条件
potassium hydroxide; Aliquatreg; 336 T=80°C; 1 h;
参考文献
Galons; Miocque; Combet-Farnoux; et al.
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 5108 - 5109
反应条件
1: 66 percent / N methanolic KOH / ethanol / 6 h / Heating 2: 86 percent / 35 percent(m/v) hydrogen peroxide, ammonium molybdate / acetic acid; H2O / 1 h / 100 °C View Scheme
参考文献
Vittorio; Pappalardo; Ronsisvalle; Caruso; Leone; Amico-Roxas
Farmaco, 1989 , vol. 44, # 10 p. 911 - 932
反应条件
1.1: potassium hydroxide / water / 0 - 5 °C 1.2: 4 h / 100 - 110 °C / Reflux 2.1: tetrahydrofuran / 0.25 h / -5 °C 2.2: 0.5 h / -5 - 20 °C 2.3: pH 2 3.1: isopropyl alcohol / 3 h / 20 - 45 °C 4.1: ammonia / water / pH ~ 9 4.2: 3 h / -5 °C View Scheme
参考文献
SHODHANA LABORATORIES LIMITED
Patent: US2011/92719 A1, 2011 ;
反应条件
potassium carbonate; toluene
参考文献
Fridman
Zhurnal Obshchei Khimii, 1953 , vol. 23, p. 284,285
engl.Ausg., vol. 297, p. 298
参考文献
Taguchi,T.; Nakao,M.
Tetrahedron, 1962 , vol. 18, p. 245 - 255
反应条件
sodium hydroxide in water T=45 - 50°C; 2 h;
参考文献
WO2007/54105 A2, ;
Page/Page column 20 ;
