N,N-二甲氨基氯丙烷盐酸盐合成路线 （共 48 条）
反应条件
water
anschliessenden Behandeln mit wss.Natronlauge;
参考文献
Andrews et al.
Journal of the Chemical Society, 1953 , p. 2998,3000
反应条件
in chlorobenzene; toluene
4 h; Heating;
参考文献
Herbert, John M.; Woodgate, Paul D.; Denny, William A.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2081 - 2086
反应条件
(i) NaOEt, EtOH, (ii) aq. KOH, (iii) /BRN= 124500/; Multistep reaction;
参考文献
Savitskaya,N.V. et al.
Pharmaceutical Chemistry Journal, 1976 , vol. 10, # 8 p. 1051 - 1056
Khimiko-Farmatsevticheskii Zhurnal, 1976 , vol. 10, # 8 p. 66 - 72
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / |Inert atmosphere
2: hydrogen; 5 palladium on charcoal / methanol / 4 h / 20 °C
View Scheme
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
反应条件
1: (i) NaOEt, EtOH, (ii) aq.KOH, (iii) /BRN= 124500/
2: cyclohexanol / 5 h / Heating
View Scheme
参考文献
Savitskaya,N.V. et al.
Pharmaceutical Chemistry Journal, 1977 , vol. 11, # 1 p. 53 - 60
Khimiko-Farmatsevticheskii Zhurnal, 1977 , vol. 11, # 1 p. 60 - 68
反应条件
1: (i) NaOEt, EtOH, (ii) aq.KOH, (iii) /BRN= 124500/
2: (i) Na, xylene, (ii) /BRN= 1088753/
View Scheme
参考文献
Savitskaya,N.V. et al.
Pharmaceutical Chemistry Journal, 1977 , vol. 11, # 1 p. 53 - 60
Khimiko-Farmatsevticheskii Zhurnal, 1977 , vol. 11, # 1 p. 60 - 68
反应条件
sodium ethanolate in ethanol
10 h; Heating;
参考文献
Savitskaya,N.V. et al.
Pharmaceutical Chemistry Journal, 1977 , vol. 11, # 1 p. 53 - 60
Khimiko-Farmatsevticheskii Zhurnal, 1977 , vol. 11, # 1 p. 60 - 68
反应条件
potassium hydroxide in ethanol
5 h; Ambient temperature;
参考文献
Da Settimo, Antonio; Da Settimo, Federico; Marini, Anna Maria; Primofiore, Giampaolo; Salerno, Silvia; Viola, Giampietro; Dalla Via, Lisa; Marciani Magno, Sebastiano
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 9 p. 685 - 696
