1,4-联苯基-1-丁酮合成路线 （共 73 条）
反应条件
1.1: POCl3; Et3N / diethyl ether / 1.25 h / -5 - 20 °C
2.1: Et3N / diethyl ether / -20 - 20 °C
3.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C
4.2: 98 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C
5.1: 84 percent / aq. H2SO4 / benzene / 4 h / Heating
View Scheme
参考文献
Grison, Claude; Thomas, Antoine; Coutrot, Frederic; Coutrot, Philippe
Tetrahedron, 2003 , vol. 59, # 12 p. 2101 - 2123
反应条件
1.1: Et3N / diethyl ether / -20 - 20 °C
2.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C
3.2: 98 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C
4.1: 84 percent / aq. H2SO4 / benzene / 4 h / Heating
View Scheme
参考文献
Grison, Claude; Thomas, Antoine; Coutrot, Frederic; Coutrot, Philippe
Tetrahedron, 2003 , vol. 59, # 12 p. 2101 - 2123
反应条件
1.1: 92 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -50 - 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C
2.2: 98 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C
3.1: 84 percent / aq. H2SO4 / benzene / 4 h / Heating
View Scheme
参考文献
Grison, Claude; Thomas, Antoine; Coutrot, Frederic; Coutrot, Philippe
Tetrahedron, 2003 , vol. 59, # 12 p. 2101 - 2123
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -50 °C
1.2: 98 percent / tetrahydrofuran; hexane / 1 h / -50 - 20 °C
2.1: 84 percent / aq. H2SO4 / benzene / 4 h / Heating
View Scheme
参考文献
Grison, Claude; Thomas, Antoine; Coutrot, Frederic; Coutrot, Philippe
Tetrahedron, 2003 , vol. 59, # 12 p. 2101 - 2123
反应条件
1: 78 percent / anhydrous ZnCl2 / tetrahydrofuran / Ambient temperature
2: Bu3SnH / benzene / 22 h / Heating
View Scheme
参考文献
Crich, David; Yao, Qingwei
Tetrahedron, 1994 , vol. 50, # 43 p. 12305 - 12312
反应条件
1: 1.) THF, -78 deg C; cyclohexane/ether, -78 deg C, 1 h
2: 2 M HCl / 1 h / Ambient temperature
3: 78 percent / anhydrous ZnCl2 / tetrahydrofuran / Ambient temperature
4: Bu3SnH / benzene / 22 h / Heating
View Scheme
参考文献
Crich, David; Yao, Qingwei
Tetrahedron, 1994 , vol. 50, # 43 p. 12305 - 12312
反应条件
3,3-dimethyldioxirane in acetone
72 h; Ambient temperature;
参考文献
Kuck, Dietmar; Schuster, Andreas
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1991 , vol. 46, # 9 p. 1223 - 1226
反应条件
1: 95 percent / K10 clay / 0.05 h / microwave irradiation
2: 93 percent / benzoic acid; 2-amino-3-picoline / (PPh3)3RhCl / 0.17 h / 140 °C / microwave irradiation
View Scheme
参考文献
Loupy, Andre; Chatti, Saber; Delamare, Sarah; Lee, Dae-Yon; Chung, Jong-Hwa; Jun, Chul-Ho
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 10 p. 1280 - 1285
反应条件
1.1: toluene-4-sulfonic acid / benzene / 23 h / Reflux; Inert atmosphere; Dean-Stark apparatus
2.1: lithium diisopropyl amide / tetrahydrofuran / 5.25 h / 0 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
2.3: 0.5 h / Cooling with ice
View Scheme
参考文献
Motiwala, Hashim F.; Guelgeze, Belgin; Aube, Jeffrey
Journal of Organic Chemistry, 2012 , vol. 77, # 16 p. 7005 - 7022
反应条件
hydrogenchloride; sodium hydroxide; oxygen; tin(ll) chloride; lithium diisopropyl amide
Yield given. Multistep reaction;
参考文献
Freerksen, Robert W.; Selikson, Sandra J.; Wroble, Randall R.; Kyler, S. Keith; Watt, David S.
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4087 - 4096
