3-[4-(叔丁氧基羰基)哌嗪-1-基]苯硼酸频那醇酯合成路线 （共 8 条）
反应条件
nitrogen; potassium acetate in P2O5; 2,4-dimethylbutane; ethyl acetate
参考文献
US2009/118305 A1, ;
US 20090118305 A1
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane
参考文献
Matasi, Julius J.; Caldwell, John P.; Zhang, Hongtao; Fawzi, Ahmad; Higgins, Guy A.; Cohen-Williams, Mary E.; Varty, Geoffrey B.; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3675 - 3678
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate T=80°C;
参考文献
Castillo, Marcos; Forns, Pilar; Erra, Montse; Mir, Marta; Lopez, Manel; Maldonado, Monica; Orellana, Adelina; Carreno, Cristina; Ramis, Isabel; Miralpeix, Montserrat; Vidal, Bernat
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 17 p. 5419 - 5423
反应条件
1: 100 percent / Pd(OAc)2; P(tBu)3; NaOtBu / toluene 2: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran 3: 80 percent / Et3N / CH2Cl2 4: 82 percent / PdCl2 (dppf); dppf; KOAc / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3675 - 3678
反应条件
1: 80 percent / Et3N / CH2Cl2 2: 82 percent / PdCl2 (dppf); dppf; KOAc / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3675 - 3678
反应条件
1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran 2: 80 percent / Et3N / CH2Cl2 3: 82 percent / PdCl2 (dppf); dppf; KOAc / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3675 - 3678
反应条件
1: 100 percent / Pd(OAc)2; P(tBu)3; NaOtBu / toluene 2: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran 3: 80 percent / Et3N / CH2Cl2 4: 82 percent / PdCl2 (dppf); dppf; KOAc / dioxane View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3675 - 3678
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 100 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 17 p. 5419 - 5423
