(3-苄氧基-4-溴-苯基)甲醇合成路线 （共 6 条）
反应条件
diisobutylaluminium hydride in hexane; dichloromethane
T=-78°C; 2 h;
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
反应条件
hydrogenchloride; diisobutylaluminium hydride in dichloromethane
参考文献
Dawson, Marcia J.; Fontana, Joseph A.; Zhang, Xiao-kun; Leid, Mark; Jong, Ling; Hobbs, Peter D.
Patent: US2003/176506 A1, 2003 ;
反应条件
1: 53 percent / Br2; AcOH / 20 h / 20 °C
2: 84 percent / K2CO3 / acetone / 15 h / Heating
3: 91 percent / DIBAL / CH2Cl2; hexane / 2 h / -78 °C
View Scheme
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
反应条件
1: 84 percent / K2CO3 / acetone / 15 h / Heating
2: 91 percent / DIBAL / CH2Cl2; hexane / 2 h / -78 °C
View Scheme
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
反应条件
1: 94 percent / MeSO3H / benzene / 10 h / Heating
2: 53 percent / Br2; AcOH / 20 h / 20 °C
3: 84 percent / K2CO3 / acetone / 15 h / Heating
4: 91 percent / DIBAL / CH2Cl2; hexane / 2 h / -78 °C
View Scheme
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
反应条件
pyridinium chlorochromate in dichloromethane
T=20°C; 5 h;
参考文献
Dawson, Marcia I.; Harris, Danni L.; Liu, Gang; Hobbs, Peter D.; Lange, Christopher W.; Jong, Ling; Bruey-Sedano, Nathalie; James, Sharon Y.; Zhang, Xiao-Kun; Peterson, Valerie J.; Leid, Mark; Farhana, Lulu; Rishi, Arun K.; Fontana, Joseph A.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3518 - 3536
