2,6-二甲基-5-庚烯腈合成路线 （共 15 条）
反应条件
(i) (tosylation), (ii) /BRN= 3587243/; Multistep reaction;
参考文献
Stork,G.; Cohen,J.F.
Journal of the American Chemical Society, 1974 , vol. 96, # 16 p. 5270 - 5272
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diethylamide
参考文献
Debal,A. et al.
Synthesis, 1976 , p. 391 - 393
参考文献
Koetz; Wunstorf
Journal fuer Praktische Chemie (Leipzig), 1913 , vol. <2> 88, p. 528
反应条件
potassium hydroxide in ethanol; water; ethylene glycol
18 h; Heating;
参考文献
Charlton, James Leslie.; Lai, Hoi Kiong.; Lypka, Gerald Nicholas
Canadian Journal of Chemistry, 1980 , vol. 58, p. 458 - 462
反应条件
1.1: 78 percent / LiHMDS / tetrahydrofuran / 1 h / 20 °C
2.1: 89 percent / DIBAL-H / diethyl ether / 0.5 h / -70 °C
3.1: 83 percent / K2CO3 / methanol / 3 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran / 1.25 h / -78 °C
4.2: 95 percent / tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Boyer, Francois-Didier; Hanna, Issam
European Journal of Organic Chemistry, 2006 , # 2 p. 471 - 482
