2-氨基-5-氯-3-硝基吡啶合成路线 （共 35 条）
反应条件
1: Na2S2O4; H2O 2: aqueous HCl View Scheme
参考文献
Vaughan et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1885
反应条件
1: Na2S2O4; H2O View Scheme
参考文献
Vaughan et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1885
反应条件
1: Na2S2O4; H2O 3: palladium; H2O / Hydrogenation View Scheme
参考文献
Vaughan et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1885
反应条件
1: 52 percent / NaNO2; conc. HBr; Br2 / 0 °C 2: 80 percent / 150 °C View Scheme
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
反应条件
1: concentrated aqueous hydrochloric acid / -10 °C / anschliessend Behandeln mit wss. Natriumnitrit-Loesung 2: iron-turnings; acetic acid View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
hydrogen bromide; bromine; sodium nitrite in water T=-5 - 0°C; 0.75 h;
参考文献
Ding, Zi-Chun; Ma, Xiang; Zhou, Weicheng
Synthetic Communications, 2012 , vol. 42, # 19 p. 2791 - 2796
反应条件
1: 83 percent / pyridine 2: 67 percent / H2 / Pd/C / ethanol View Scheme
参考文献
Cundy, Darren J.; Holan, George; Otaegui, Michelle; Simpson, Gregory W.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 669 - 674
反应条件
pyridine; trifluoroacetic anhydride in chloroform; trifluoroacetic acid
参考文献
Eli Lilly and Company
Patent: US4087432 A1, 1978 ;
反应条件
pyridine in chloroform
参考文献
Eli Lilly and Company
Patent: US4087432 A1, 1978 ;
参考文献
Cundy, Darren J.; Holan, George; Otaegui, Michelle; Simpson, Gregory W.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 669 - 674
