2-氨基-5-氯-3-硝基吡啶合成路线 （共 35 条）
反应条件
1: hydrogen bromide; bromine; sodium nitrite / water / 0.75 h / -5 - 0 °C 2: iron; acetic acid / 60 °C 3: pyridine / dichloromethane / 1 h / 0 - 20 °C 4: tetraphosphorus decasulfide / toluene / 0.5 h / 110 °C View Scheme
参考文献
Synthetic Communications, , vol. 42, # 19 p. 2791 - 2796
反应条件
1: With hydrogenchloride in water T=-10°C; 2: With sodium nitrite in water T=0°C; 2 h; 3: With sodium hydroxide in water T=-10 - 0°C; pH=9;
参考文献
GLAXO GROUP LIMTED
Patent: WO2007/67875 A2, 2007 ;
Location in patent: Page/Page column 15 ;
WO 2007/067875 A2
反应条件
hydrogenchloride; sodium nitrite T=-15°C;
参考文献
Hussenether, Thomas; Huebner, Harald; Gmeiner, Peter; Troschuetz, Reinhard
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2625 - 2637
反应条件
hydrogen; nickel in methanol P=1034.3 - 2068.6 Torr; 3 h;
参考文献
Cai, Sui Xiong; Huang, Jin-Cheng; Espitia, Stephen A.; Tran, Minhtam; Ilyin, Victor I.; Hawkinson, Jon E.; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3679 - 3686
参考文献
Tschitschibabin; Kirssanow
Chemische Berichte, 1927 , vol. 60, p. 775
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1927 , vol. 59, p. 417
反应条件
sulfuric acid; water; sodium nitrite
参考文献
Jones et al.
Journal of the American Pharmaceutical Association (1912-1977), 1949 , vol. 38, p. 70
Full Text Show Details
Berrie et al.
Journal of the Chemical Society, 1951 , p. 2590,2593
反应条件
1: Na2S2O4; H2O 3: palladium/CaCO3 / Hydrogenation View Scheme
参考文献
Vaughan et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1885
反应条件
1: Na2S2O4; H2O 2: Diazotization 3: platinum/charcoal; palladium/charcoal; aq. NaOH solution / Hydrogenation View Scheme
参考文献
Vaughan et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1885
反应条件
1: 52 percent / NaNO2; conc. HBr; Br2 / 0 °C
2: 80 percent / 150 °C
3: 95 percent / H2 / Raney nickel / aq. ethanol / 2.5 h / 2327.17 Torr
4: 85 percent / conc. HCl / 17 h / Heating
5: 87 percent / conc. H2SO4 / 12 h / Heating
View Scheme
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
反应条件
1: 52 percent / NaNO2; conc. HBr; Br2 / 0 °C
2: 80 percent / 150 °C
3: 95 percent / H2 / Raney nickel / aq. ethanol / 2.5 h / 2327.17 Torr
View Scheme
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
