3-(N-苄基-N-甲基氨基)苯丙酮盐酸盐合成路线 （共 6 条）
反应条件
hydrogen; 5 PdCl2 on carbon in water; ethyl acetate T=55 - 57°C; P=2206.72 - 2574.5 Torr; 1 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/37055 A1, 2006 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1: H2, <Rh(COD)Cl>2, (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine / methanol / 48 h / 50 °C / 22800 Torr 2: H2 / 5percent Pd/C / ethanol / 20 h / Ambient temperature 3: 1.) NaH / 1.) N,N-dimethylacetamide, a) 0 deg C, 5 min, b) 70 deg C, 30 min, 2.) N,N-dimethylacetamide, 100 deg C, 3 h View Scheme
参考文献
Sakuraba; Achiwa
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 5 p. 748 - 753
反应条件
hydrogenchloride in propan-1-ol
T=100 - 110°C; Mannich reaction; 2 h;
参考文献
Sharma; Bhandari, Kalpana; Shankar, Girija; Singh; Srivastava, Pratima; Pandey
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 1 p. 207 - 211
反应条件
in ethanol
T=82°C; 5 h;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US2006/9533 A1, 2006 ;
Location in patent: Page/Page column 5 ;
反应条件
1: H2 / Pd/C
2: 92 percent / HCl / propan-1-ol / 2 h / 100 - 110 °C
View Scheme
参考文献
Sharma; Bhandari, Kalpana; Shankar, Girija; Singh; Srivastava, Pratima; Pandey
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 1 p. 207 - 211
反应条件
1: H2 / Pd/C
2: 92 percent / HCl / propan-1-ol / 2 h / 100 - 110 °C
View Scheme
参考文献
Sharma; Bhandari, Kalpana; Shankar, Girija; Singh; Srivastava, Pratima; Pandey
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 1 p. 207 - 211
