2-溴-5-(4-甲氧基苯基)噻吩合成路线 （共 5 条）
反应条件
copper(l) iodide; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=60°C; 8 h;
参考文献
Kobayashi, Kei; Mohamed Ahmed, Mohamed S.; Mori, Atsunori
Tetrahedron, 2006 , vol. 62, # 41 p. 9548 - 9553
反应条件
pyridine in N,N-dimethyl-formamide 16 h; Reflux;
参考文献
Dai, Heng; Yang, Xueyan; Tan, Xiaoping; Su, Fawu; Cheng, Xiaohong; Liu, Feng; Tschierske, Carsten
Chemical Communications, 2013 , vol. 49, # 90 p. 10617 - 10619
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in water; toluene
T=100°C; Suzuki coupling; 4 h; Inert atmosphere;
参考文献
UNIVERSITAT DES SAARLANDES
Patent: US2011/46147 A1, 2011 ;
Location in patent: Page/Page column 25 ;
反应条件
potassium fluoride; silver nitrate; PdCl2(PPh)3 in dimethyl sulfoxide
T=100°C; 8 h;
参考文献
Kobayashi, Kei; Mohamed Ahmed, Mohamed S.; Mori, Atsunori
Tetrahedron, 2006 , vol. 62, # 41 p. 9548 - 9553
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in tetrahydrofuran; water
Suzuki coupling; 20 h; Inert atmosphereReflux;
参考文献
Bey, Emmanuel; Marchais-Oberwinkler, Sandrine; Werth, Ruth; Negri, Matthias; Al-Soud, Yaseen A.; Kruchten, Patricia; Oster, Alexander; Frotscher, Martin; Birk, Barbara; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6725 - 6739
