(R,R)-2-[Bn-(2-hydroxy-2-Ph-ethyl)-amino]-1-phenyl-ethanol; tetra-N-butylammonium borohydride in tetrahydrofuran T=0°C; Michael addition; 7 h; Title compound not separated from byproducts;
1: malonic acid di(tert-butyl)-ester With sodium hydride in tetrahydrofuran; mineral oil T=20°C; 0.5 h; 2: methyl iodide in tetrahydrofuran; mineral oil T=20°C; 2 h;
参考文献
Qabaja, Ghassan; Wilent, Jennifer E.; Benavides, Amanda R.; Bullard, George E.; Petersen, Kimberly S.
Organic Letters, 2013 , vol. 15, # 6 p. 1266 - 1269