反应条件
1: malonic acid di(tert-butyl)-ester With N,N,N',N',N'',N''-hexamethylphosphoric triamide; sodium hydride in 1,4-dioxane
T=20°C; 1 h;
2: 4-bromo-1-iodobenzene With copper(I) bromide in 1,4-dioxane
3 h; Heating;
参考文献
Shi, Zhen-Dan; Wei, Chang-Qing; Lee, Kyeong; Liu, Hongpeng; Zhang, Manchao; Araki, Toshiyuki; Roberts, Lindsey R.; Worthy, Karen M.; Fisher, Robert J.; Neel, Benjamin G.; Kelley, James A.; Yang, Dajun; Burke Jr., Terrence R.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2166 - 2169