反应条件
1: (S)-N5-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-ornithine; chloroformic acid ethyl ester With 4-methyl-morpholine in tetrahydrofuran T=-15°C; 0.5 h; 2: (S)-2-carbomethoxypyrrolidine hydrochloride With 4-methyl-morpholine in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 6 h; 3: With trifluoroacetic acid 0.25 h; Title compound not separated from byproducts;
参考文献
Reid, Robert C.; Abbenante, Giovanni; Taylor, Stephen M.; Fairlie, David P.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4464 - 4471