1: 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine With n-butyllithium in tetrahydrofuran; hexane T=-65°C; 0.5 h; Inert atmosphere; 2: chloroformic acid ethyl ester in tetrahydrofuran; hexane T=20°C; 3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
Mitsubishi Tanabe Pharma Corporation
Patent: EP2390254 A1, 2011 ;
Location in patent: Page/Page column 67 ;
EP 2390254 A1