2,5-二甲基-对苯二甲酸 二甲酯合成路线 （共 6 条）
反应条件
1: in methanol; hexanes; diethyl ether
T=0 - 20°C; 0.5 h;
2: With acetic acid in methanol; hexanes; diethyl ether
参考文献
EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 404-405 ;
反应条件
thionyl chloride
3 h; Heating / reflux;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1403255 A1, 2004 ;
Location in patent: Page 129 ;
EP 1403255 A1
反应条件
1: KOH / bis-(2-hydroxy-ethyl) ether / Heating
2: MeSO3H / 10 h / Heating
View Scheme
参考文献
Ngola, Sarah M.; Kearney, Patrick C.; Mecozzi, Sandro; Russell, Keith; Dougherty, Dennis A.
Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1192 - 1201
反应条件
1: 81 percent / dimethylformamide / 48 h / Heating
2: KOH / bis-(2-hydroxy-ethyl) ether / Heating
3: MeSO3H / 10 h / Heating
View Scheme
参考文献
Ngola, Sarah M.; Kearney, Patrick C.; Mecozzi, Sandro; Russell, Keith; Dougherty, Dennis A.
Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1192 - 1201
反应条件
(i) H2, Pd-BaSO4, (ii) /BRN= 1098229/, aq. HCl; Multistep reaction;
参考文献
Kuhn,R.; Butula,I.
Justus Liebigs Annalen der Chemie, 1968 , vol. 718, p. 50 - 77
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in dichloromethane
2 h; Reflux;
参考文献
Muranaka, Atsuya; Shibahara, Masahiko; Watanabe, Motonori; Matsumoto, Taisuke; Shinmyozu, Teruo; Kobayashi, Nagao
Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 9125 - 9128
