5-氯-1(3h)-异苯并呋喃酮合成路线 （共 22 条）
反应条件
NaCN; triphenylphosphine; nickel dichloride in tetrahydrofuran; water; acetonitrile
参考文献
H. Lundbeck A/S
Patent: US2002/198391 A1, 2002 ;
反应条件
4-(N,N-dimethlyamino)pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; N-ethyl-N,N-diisopropylamine; palladium diacetate in 1,4-dioxane
T=150°C; 0.5 h; microwave irradiation;
参考文献
Wu, Xiongyu; Mahalingam; Wan, Yiqian; Alterman, Mathias
Tetrahedron Letters, 2004 , vol. 45, # 24 p. 4635 - 4638
反应条件
palladium diacetate; potassium hydrogencarbonate
T=140°C; 36 h;
参考文献
Zhang, Yang-Hui; Shi, Bing-Feng; Yu, Jin-Quan
Angewandte Chemie, International Edition, 2009 , vol. 48, # 33 p. 6097 - 6100
Angewandte Chemie, 2009 , vol. 121, # 33 p. 6213 - 6216
反应条件
sodium tetrahydroborate in N,N-dimethyl-formamide
T=20°C; 1 h;
参考文献
Donati, Cosimo; Prager, Rolf H.; Weber, Ben
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 787 - 795
反应条件
potassium borohydride in methanol
1 h; Heating;
参考文献
Epsztajn, Jan; Bieniek, Adam; Kowalska, Justyna A.; Scianowski, Jacek
Monatshefte fuer Chemie, 1992 , vol. 123, # 12 p. 1125 - 1134
反应条件
ueber die Diazonium-Verbindung;
参考文献
Levy; Stephen
Journal of the Chemical Society, 1931 , p. 867,869
反应条件
hydrogenchloride; acetic acid; zinc in water
参考文献
Nikulin, V. I.; Pisarenko, L. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985 , vol. 34, # 1 p. 141 - 144
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985 , # 1 p. 151 - 155
反应条件
oxygen in acetic acid; xylene
T=35 - 40°C; Purification / work up;
参考文献
General Electric Company
Patent: US6670487 B1, 2003 ;
Location in patent: Page column 15 ;
反应条件
hydrogenchloride
T=90°C; 0.5 h; Yield given;
参考文献
Cherkez, S.; Herzig, J.; Yellin, H.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 947 - 959
反应条件
1: 33 percent / dimethylformamide / 2 h / 160 °C
2: 34 percent / AcOH, Zn / methanol / 6 h / 45 °C
3: Zn, CuSO4*5H2O, aq. NaOH / 1 h / 90 °C
4: concd. HCl / 0.5 h / 90 °C
View Scheme
参考文献
Cherkez, S.; Herzig, J.; Yellin, H.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 947 - 959
