sodium hydrogencarbonate; sodium bromide; chiral 4,1'-dinaphthyl-3,2'-cyclo[C(Me)2-N(oxyl)-C(Me)2] in dichloromethane; water T=-15°C; resolution of racemate; 1.5 h; Electrolysis; Title compound not separated from byproducts;
1: With bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; (+)-1-[6-(diphenylphosphanyl)-4,7-dimethyl-2-(toluene-4-sulfonyl)-2,3-dihydro-1H-isoindol-5-yl]-8-methylisoquinoline; benzo[1,3,2]dioxaborole in toluene T=20°C; 2 h; Inert atmosphere; 2: With dihydrogen peroxide; sodium hydroxide in ethanol; water T=20°C; 2.5 h; Cooling with ice; optical yield given as percent ee;
参考文献
Chemistry - A European Journal, , vol. 17, # 5 p. 1428 - 1432
