4-溴-7-甲氧基-1-茚酮合成路线 （共 15 条）
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in ethanol P=3102.89 Torr; 4 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 13 p. 3415 - 3418
参考文献
Meyer; DeBernardis; Hancock
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 105 - 112
反应条件
1: 91 percent / bromine / CH2Cl2 / 0.25 h / 0 °C
2: 66 percent / polyphosphoric acid / 1 h / 60 °C
View Scheme
参考文献
Meyer; DeBernardis; Hancock
Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 105 - 112
参考文献
Barnes; Kraft; Gordon
Journal of the American Chemical Society, 1949 , vol. 71, p. 3523,3527
反应条件
2: tetrachloromethane; bromine / -10 °C
3: liquid hydrogen fluoride
View Scheme
参考文献
Barnes; Kraft; Gordon
Journal of the American Chemical Society, 1949 , vol. 71, p. 3523,3527
反应条件
1: 95 percent / Br2 / acetic acid; H2O
2: 71 percent / methylation
3: 1) LDA / 1) THF, hexane, 10 min 2) r.t., 12 h
View Scheme
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
反应条件
1: 68 percent / NBS, Azobis(isobutyronitril) / 2 h / Heating
2: 1) NaOEt / 1) EtOH 2) CCl4, reflux, 2 h
3: 96 percent / 5percent aq.NaOH / 4 h / 80 °C
4: 97 percent / 180 °C
5: 14 percent / Polyphosphorsaeure / 12 h / 80 °C
6: 1) LDA / 1) THF, hexane, 10 min 2) r.t., 12 h
View Scheme
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
反应条件
1: 1) NaOEt / 1) EtOH 2) CCl4, reflux, 2 h
2: 96 percent / 5percent aq.NaOH / 4 h / 80 °C
3: 97 percent / 180 °C
4: 14 percent / Polyphosphorsaeure / 12 h / 80 °C
5: 1) LDA / 1) THF, hexane, 10 min 2) r.t., 12 h
View Scheme
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
反应条件
1: 14 percent / Polyphosphorsaeure / 12 h / 80 °C
2: 1) LDA / 1) THF, hexane, 10 min 2) r.t., 12 h
View Scheme
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
反应条件
1: 71 percent / methylation
2: 1) LDA / 1) THF, hexane, 10 min 2) r.t., 12 h
View Scheme
参考文献
Pudleiner, Heinz; Laatsch, Hartmut
Liebigs Annalen der Chemie, 1990 , # 5 p. 423 - 432
