4,5-二溴呋喃-2-羧酸甲酯合成路线 （共 12 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran Ambient temperature;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/17818 A1, 2009 ;
Location in patent: Page/Page column 49-50 ;
反应条件
ammonium chloride; zinc in methanol T=20°C; 2.5 h; Inert atmosphere;
参考文献
Brucoli, Federico; Natoli, Antonino; Marimuthu, Preethi; Borrello, Maria Teresa; Stapleton, Paul; Gibbons, Simon; Schaetzlein, Andreas
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2019 - 2024
反应条件
tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane; cesium fluoride in toluene T=100°C; Hiyama cross-coupling; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Schweizer, Stefan A.; Bach, Thorsten
Synlett, 2010 , # 1 p. 81 - 84
反应条件
sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; palladium in methanol; benzene T=20°C; Rate constant;
参考文献
Sharf, V. Z.; Belen'kii, L. I.; Gurovets, A. S.; Karmanova, I. B.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 2 p. 134 - 138
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 2 p. 176 - 180
反应条件
sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; palladium in methanol; benzene T=20°C; Rate constant;
参考文献
Sharf, V. Z.; Belen'kii, L. I.; Gurovets, A. S.; Karmanova, I. B.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 2 p. 134 - 138
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 2 p. 176 - 180
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 4 h; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C;
参考文献
Allison, Brett; Phuong, Victor K.; Pippel, Marna C.W.; Rabinowitz, Michael H.; Venkatesan, Hariharan
Patent: US2006/69286 A1, 2006 ;
Location in patent: Page/Page column 25 ;
US 20060069286 A1
反应条件
1: With sulfuric acid in methanol
T=20°C; 7 h; Heating / reflux;
2: With sodium hydroxide; anhydrous trisodium citrate in methanol; tert-butyl methyl ether; water
T=0°C; pH=6;
参考文献
PHARMACIA ITALIA S.P.A.
Patent: WO2004/7504 A1, 2004 ;
Location in patent: Page 54-55 ;
WO 2004/007504 A1
反应条件
AlCl3, aluminium chloride; bromine
T=0°C; 1 h; Inert atmosphere;
参考文献
Brucoli, Federico; Natoli, Antonino; Marimuthu, Preethi; Borrello, Maria Teresa; Stapleton, Paul; Gibbons, Simon; Schaetzlein, Andreas
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2019 - 2024
反应条件
1: furan-5alpha-carboxylic acid methyl ester With AlCl3, aluminium chloride; bromine
1 h; Neat (no solvent);
2: water T=0°C;
参考文献
Allison, Brett; Phuong, Victor K.; Pippel, Marna C.W.; Rabinowitz, Michael H.; Venkatesan, Hariharan
Patent: US2006/69286 A1, 2006 ;
Location in patent: Page/Page column 24-25 ;
US 20060069286 A1
反应条件
bromine in tetrachloromethane
28 h; Heating;
参考文献
Bury, Paul; Hareau, Georges; Kocienski, Philip; Dhanak, Dashyant
Tetrahedron, 1994 , vol. 50, # 29 p. 8793 - 8808
