4-溴-4’-甲氧基二苯甲酮合成路线 （共 18 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=5 - 20°C; Friedel Crafts Acylation; 3 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/12220 A2, 2005 ;
Location in patent: Page/Page column 39 ;
WO 2005/012220 A2
反应条件
2,6-di-tert-butyl-4-methyl-phenol; 4 A molecular sieve; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=95°C; P=760 Torr; 27 h;
参考文献
Journal of the American Chemical Society, , vol. 110, p. 1557
反应条件
palladium 10 on activated carbon; triethylamine; triphenylphosphine in tetrahydrofuran T=80°C; 3 h; Inert atmosphere;
参考文献
Rao, Maddali L.N.; Jadhav, Deepak N.; Venkatesh, Varadhachari
Tetrahedron Letters, 2009 , vol. 50, # 29 p. 4268 - 4271
反应条件
potassium phosphate; platinacycle; pentan-3-one in toluene T=90 - 100°C;
参考文献
Liao, Yuan-Xi; Hu, Qiao-Sheng
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 6986 - 6989
反应条件
CO; dichloro{1,1'-bis(diphenylphosphino)ferrocene}palladium(II) in N,N-dimethyl-formamide the triflate and the stannane in DMF contg. the Pd catalyst and LiCl heated at 100°C under 1 atm CO for 30 h; cooled to room temp., dild. with ether, filtered, filtrate washed with water and satd. NaCl soln., dried, concd., chromd. (flash column, hexanes/EtOAc);
参考文献
Echavarren,A.M.; Stille,J.K.
Journal of the American Chemical Society, 1988 , vol. 110, p. 1557
反应条件
palladium diacetate; SIDip*HCl in 1,4-dioxane T=100°C; P=760 Torr; 5 h;
参考文献
Tetrahedron Letters, , vol. 43, # 50 p. 9137 - 9140
反应条件
dichloro bis(acetonitrile) palladium(II) in tetrahydrofuran T=55°C; 16 h;
参考文献
Fausett, Bryan W.; Liebeskind, Lanny S.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4851 - 4853
反应条件
LiCl; CO; dichloro{1,1'-bis(diphenylphosphino)ferrocene}palladium(II) in N,N-dimethyl-formamide the triflate and the stannane in DMF contg. the Pd catalyst and LiCl heated at 95°C under 1 atm CO for 27 h; cooled to room temp., dild. with ether, filtered, filtrate washed with water and satd. NaCl soln., dried, concd., chromd. (flash column, hexanes/EtOAc);
参考文献
Journal of the American Chemical Society, , vol. 110, p. 1557
反应条件
trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) in toluene T=23°C; Fukuyama reaction; Inert atmosphere;
参考文献
Kunchithapatham, Kamala; Eichman, Chad C.; Stambuli, James P.
Chemical Communications, 2011 , vol. 47, # 47 p. 12679 - 12681
反应条件
1: With trifluoroacetic anhydride T=80°C; 2: With boron trifluoride diethyl etherate T=80°C; Friedel-Crafts reaction; Title compound not separated from byproducts;
参考文献
Synlett, , # 7 p. 1063 - 1066
