4-溴-4’-甲氧基二苯甲酮合成路线 （共 18 条）
反应条件
1: triethylamine / hexane / 12.5 h / 0 - 23 °C 2: trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) / toluene / 23 °C / Inert atmosphere View Scheme
参考文献
Chemical Communications, , vol. 47, # 47 p. 12679 - 12681
反应条件
1: thionyl chloride / 3 h / 20 °C 2: AlCl3, aluminium chloride / dichloromethane / 16 h / 20 °C / |Inert atmosphere View Scheme
反应条件
chloroacetic acid anhydride T=170 - 180°C;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 504, p. 267,282
反应条件
1: 73 percent / pyridine / CH2Cl2 / 16 h / 0 - 20 °C View Scheme
参考文献
Boeger, Manfred; Duerr, Dieter; Gsell, Laurenz; Hall, Roger G.; Karrer, Friedrich; Kristiansen, Odd; Maienfisch, Peter; Pascual, Alfons; Rindlisbacher, Alfred
Pest Management Science, 2001 , vol. 57, # 2 p. 191 - 202
反应条件
1: (i) DMF, (ii) FeCl3, aq. HCl 2: HCl / Heating View Scheme
参考文献
Diana; Carabateas; Johnson; Williams; Pancic; Collins
Journal of Medicinal Chemistry, 1978 , vol. 21, # 9 p. 889 - 894
反应条件
(i) DMF, (ii) FeCl3, aq. HCl; Multistep reaction;
参考文献
Diana; Carabateas; Johnson; Williams; Pancic; Collins
Journal of Medicinal Chemistry, 1978 , vol. 21, # 9 p. 889 - 894
反应条件
1: (i) DMF, (ii) FeCl3, aq. HCl
2: HCl / Heating
3: H2 / Pd-C / ethanol
4: aq. NaOH / ethanol / Heating
View Scheme
参考文献
Diana; Carabateas; Johnson; Williams; Pancic; Collins
Journal of Medicinal Chemistry, 1978 , vol. 21, # 9 p. 889 - 894
反应条件
1: 6 h / 175 °C
2: potassium hydroxide / methanol / 6 h / 175 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; DANG, Qun; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia
Patent: WO2013/43624 A1, 2013 ;
