b-氧代-a-苯基苯丙腈合成路线 （共 38 条）
反应条件
1: benzoic acid phenyl ester With potassium tert-butylate in tetrahydrofuran; water
2: phenylacetonitrile in tetrahydrofuran; water
T=20°C; 0.5 h;
参考文献
Kim, Bo Ram; Lee, Hyung-Geun; Kang, Seung-Beom; Jung, Kwang-Ju; Sung, Gi Hyeon; Kim, Jeum-Jong; Lee, Sang-Gyeong; Yoon, Yong-Jin
Tetrahedron, 2013 , vol. 69, # 48 p. 10331 - 10336
反应条件
1: benzoic acid anhydride With potassium tert-butylate in tetrahydrofuran; water
2: phenylacetonitrile in tetrahydrofuran; water
T=20°C; 0.5 h;
参考文献
Kim, Bo Ram; Lee, Hyung-Geun; Kang, Seung-Beom; Jung, Kwang-Ju; Sung, Gi Hyeon; Kim, Jeum-Jong; Lee, Sang-Gyeong; Yoon, Yong-Jin
Tetrahedron, 2013 , vol. 69, # 48 p. 10331 - 10336
反应条件
1: benzoic acid With potassium tert-butylate in tetrahydrofuran; water
2: phenylacetonitrile in tetrahydrofuran; water
T=20°C; 0.5 h;
参考文献
Kim, Bo Ram; Lee, Hyung-Geun; Kang, Seung-Beom; Jung, Kwang-Ju; Sung, Gi Hyeon; Kim, Jeum-Jong; Lee, Sang-Gyeong; Yoon, Yong-Jin
Tetrahedron, 2013 , vol. 69, # 48 p. 10331 - 10336
反应条件
polymeric trityllithium in tetrahydrofuran
Ambient temperature;
参考文献
Cohen, B. J.; Kraus, M. A.; Patchornik, A.
Journal of the American Chemical Society, 1981 , vol. 103, # 25 p. 7620 - 7629
反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran
T=-78°C; 0.25 h;
2: Phenyl[2-(trimethylsilyl)phenyl]iodonium trifluoromethanesulfonate With tetrabutyl ammonium fluoride in tetrahydrofuran
T=0 - 20°C; 0.916667 h;
3: benzoyl chloride in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Kamila, Sukanta; Koh, Benjamin; Biehl, Edward R.
Synthetic Communications, 2006 , vol. 36, # 23 p. 3493 - 3507
反应条件
triphenylmethyllithium
1) THF; Yield given. Multistep reaction;
参考文献
Cohen, B. J.; Kraus, M. A.; Patchornik, A.
Journal of the American Chemical Society, 1981 , vol. 103, # 25 p. 7620 - 7629
反应条件
tributylphosphine; sodium hydride
1.) 1 h, 0 deg C then 2 h, rt.; 2.) DMF, 2 h, rt.;
参考文献
Yokoyama, Masataka; Hoshi, Kazuko; Imamoto, Tsuneo
Chemistry Letters, 1982 , p. 1615 - 1616
反应条件
1: 1.) n-BuLi, tetramethylethylenediamine, 3.) aq. 20percent HCl
2: 96 percent / dimethylformamide / 16 h / 80 °C
3: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, RT, 1 h
View Scheme
参考文献
Miyashita, Akira; Suzuki, Yumiko; Nagasaki, Izuru; Ishiguro, Chie; Iwamoto, Ken-Ichi; Higashino, Takeo
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 8 p. 1254 - 1258
反应条件
1: 96 percent / dimethylformamide / 16 h / 80 °C
2: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, RT, 1 h
View Scheme
参考文献
Miyashita, Akira; Suzuki, Yumiko; Nagasaki, Izuru; Ishiguro, Chie; Iwamoto, Ken-Ichi; Higashino, Takeo
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 8 p. 1254 - 1258
反应条件
in 1,2-dichloro-benzene
24 h; Heating;
参考文献
Belinka, Benjamin A.; Hassner, Alfred; Hendler, J. M.
Journal of Organic Chemistry, 1981 , vol. 46, # 3 p. 631 - 632
