乙基1-氨基-2-环戊烯-1-羧酸酯合成路线 （共 4 条）
反应条件
1: 57 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
2: 90 percent / DBU / toluene / 48 h / Heating
3: 4.93 g / aq. NaOH / ethanol / 15 h / 20 °C
4: Et3N / acetone / 0.5 h / 20 °C
5: aq. NaN3 / acetone / 1 h / 0 °C
6: benzene / 3 h / Heating
7: 2.05 g / aq. HCl / tetrahydrofuran
View Scheme
参考文献
Conti, Paola; Roda, Gabriella; Stabile, Helena; Vanoni, Maria Antonietta; Curti, Bruno; De Amici, Marco
Farmaco, 2003 , vol. 58, # 9 p. 683 - 690
反应条件
1: 47 percent / NaBH4 / ethanol / 0.5 h / 0 °C
2: 57 percent / Et3N / CH2Cl2 / 0.5 h / 20 °C
3: 90 percent / DBU / toluene / 48 h / Heating
4: 4.93 g / aq. NaOH / ethanol / 15 h / 20 °C
5: Et3N / acetone / 0.5 h / 20 °C
6: aq. NaN3 / acetone / 1 h / 0 °C
7: benzene / 3 h / Heating
8: 2.05 g / aq. HCl / tetrahydrofuran
View Scheme
参考文献
Conti, Paola; Roda, Gabriella; Stabile, Helena; Vanoni, Maria Antonietta; Curti, Bruno; De Amici, Marco
Farmaco, 2003 , vol. 58, # 9 p. 683 - 690
反应条件
1: 4.93 g / aq. NaOH / ethanol / 15 h / 20 °C
2: Et3N / acetone / 0.5 h / 20 °C
3: aq. NaN3 / acetone / 1 h / 0 °C
4: benzene / 3 h / Heating
5: 2.05 g / aq. HCl / tetrahydrofuran
View Scheme
参考文献
Conti, Paola; Roda, Gabriella; Stabile, Helena; Vanoni, Maria Antonietta; Curti, Bruno; De Amici, Marco
Farmaco, 2003 , vol. 58, # 9 p. 683 - 690
反应条件
1: 90 percent / DBU / toluene / 48 h / Heating
2: 4.93 g / aq. NaOH / ethanol / 15 h / 20 °C
3: Et3N / acetone / 0.5 h / 20 °C
4: aq. NaN3 / acetone / 1 h / 0 °C
5: benzene / 3 h / Heating
6: 2.05 g / aq. HCl / tetrahydrofuran
View Scheme
参考文献
Conti, Paola; Roda, Gabriella; Stabile, Helena; Vanoni, Maria Antonietta; Curti, Bruno; De Amici, Marco
Farmaco, 2003 , vol. 58, # 9 p. 683 - 690
