1.1: 95.1 g / aq. HCl / dimethylformamide / 3 h / 90 °C 2.1: 80 percent / pyridine; TFA; DCC / CHCl3 / 1 h / 10 °C 3.1: Zn; Br2 / tetrahydrofuran; toluene / 1 h / 50 - 60 °C 3.2: Pd/C D1 / tetrahydrofuran; toluene; dimethylformamide / 5 h / 28 - 40 °C 3.3: 94 percent / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 1 h / 20 °C 4.1: H2 / Pd(OH)2/C / aq. methanol / 12 h / 110 °C / 6750.54 Torr 5.1: 85 g / aq. NaOH / methanol / 2 h / 40 °C 6.1: 74 percent / MeSO3H / 1,3,5-trimethyl-benzene / 3 h / 135 °C View Scheme