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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
54154-44-8
合成路线
（共 5 条）
54154-44-8
→
反应条件
138568-27-1
反应条件
potassium carbonate; thiophenol in 1-methyl-pyrrolidin-2-one T=220°C; 13 h;
参考文献
Kawashima, Hidehisa; Kaneko, Yuki; Sakai, Masahiro; Kobayashi, Yuichi
Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 272 - 278
135432-16-5
→
反应条件
54154-44-8
反应条件
<b>Multi-step reaction with 12 steps<br /> </b>1.1: dihydrogen peroxide; pyridine / dichloromethane / 20 °C / |Cooling with ice<br />2.1: copper(l) iodide / tetrahydrofuran / 0.5 h / -78 °C<br />2.2: 2 h / -78 - -50 °C<br />3.1: boron trifluoride diethyl etherate / acetic anhydride / 20 °C / |Cooling with ice<br />4.1: sodium hydride; methanol / mineral oil / 0.5 h / 20 °C<br />5.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.17 h / 0 °C<br />5.2: 1 h / |Reflux<br />6.1: potassium hydroxide / propan-1-ol / 1 h / 20 °C / |Reflux<br />7.1: ethyl acetate; diethyl ether / 0.08 h / 0 °C<br />8.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C<br />8.2: 0.5 h / -78 °C<br />9.1: sodium hydrogencarbonate / para-xylene / 12 h / |Reflux<br />10.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C<br />11.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 17 h / |Reflux<br />12.1: sodium tetrahydroborate / N,N-dimethyl-formamide / 12 h / 80 °C / |Cooling with ice<br /> <br />
参考文献
Kawashima, Hidehisa; Kaneko, Yuki; Sakai, Masahiro; Kobayashi, Yuichi Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 272 - 278
35408-03-8
→
反应条件
54154-44-8
反应条件
<b>Multi-step reaction with 11 steps<br /> </b>1.1: copper(l) iodide / tetrahydrofuran / 0.5 h / -78 °C<br />1.2: 2 h / -78 - -50 °C<br />2.1: boron trifluoride diethyl etherate / acetic anhydride / 20 °C / |Cooling with ice<br />3.1: sodium hydride; methanol / mineral oil / 0.5 h / 20 °C<br />4.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.17 h / 0 °C<br />4.2: 1 h / |Reflux<br />5.1: potassium hydroxide / propan-1-ol / 1 h / 20 °C / |Reflux<br />6.1: ethyl acetate; diethyl ether / 0.08 h / 0 °C<br />7.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C<br />7.2: 0.5 h / -78 °C<br />8.1: sodium hydrogencarbonate / para-xylene / 12 h / |Reflux<br />9.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C<br />10.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 17 h / |Reflux<br />11.1: sodium tetrahydroborate / N,N-dimethyl-formamide / 12 h / 80 °C / |Cooling with ice<br /> <br />
参考文献
Kawashima, Hidehisa; Kaneko, Yuki; Sakai, Masahiro; Kobayashi, Yuichi Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 272 - 278
18172-67-3
(-)-β-蒎烯
→
反应条件
54154-44-8
反应条件
<b>Multi-step reaction with 14 steps<br /> </b>1.1: ruthenium(III) chloride*(x)H<sub>2</sub>O; sodium periodate / tetrachloromethane; acetonitrile; water / 2 h / 20 °C<br />2.1: selenium(IV) oxide; sulfuric acid / methanol / 5 h / 20 °C / |Cooling with ice<br />3.1: dihydrogen peroxide; pyridine / dichloromethane / 20 °C / |Cooling with ice<br />4.1: copper(l) iodide / tetrahydrofuran / 0.5 h / -78 °C<br />4.2: 2 h / -78 - -50 °C<br />5.1: boron trifluoride diethyl etherate / acetic anhydride / 20 °C / |Cooling with ice<br />6.1: sodium hydride; methanol / mineral oil / 0.5 h / 20 °C<br />7.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.17 h / 0 °C<br />7.2: 1 h / |Reflux<br />8.1: potassium hydroxide / propan-1-ol / 1 h / 20 °C / |Reflux<br />9.1: ethyl acetate; diethyl ether / 0.08 h / 0 °C<br />10.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C<br />10.2: 0.5 h / -78 °C<br />11.1: sodium hydrogencarbonate / para-xylene / 12 h / |Reflux<br />12.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C<br />13.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 17 h / |Reflux<br />14.1: sodium tetrahydroborate / N,N-dimethyl-formamide / 12 h / 80 °C / |Cooling with ice<br /> <br />
参考文献
Kawashima, Hidehisa; Kaneko, Yuki; Sakai, Masahiro; Kobayashi, Yuichi Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 272 - 278
38651-65-9
(1R)-(+)-诺蒎酮
→
反应条件
54154-44-8
反应条件
<b>Multi-step reaction with 13 steps<br /> </b>1.1: selenium(IV) oxide; sulfuric acid / methanol / 5 h / 20 °C / |Cooling with ice<br />2.1: dihydrogen peroxide; pyridine / dichloromethane / 20 °C / |Cooling with ice<br />3.1: copper(l) iodide / tetrahydrofuran / 0.5 h / -78 °C<br />3.2: 2 h / -78 - -50 °C<br />4.1: boron trifluoride diethyl etherate / acetic anhydride / 20 °C / |Cooling with ice<br />5.1: sodium hydride; methanol / mineral oil / 0.5 h / 20 °C<br />6.1: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.17 h / 0 °C<br />6.2: 1 h / |Reflux<br />7.1: potassium hydroxide / propan-1-ol / 1 h / 20 °C / |Reflux<br />8.1: ethyl acetate; diethyl ether / 0.08 h / 0 °C<br />9.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C<br />9.2: 0.5 h / -78 °C<br />10.1: sodium hydrogencarbonate / para-xylene / 12 h / |Reflux<br />11.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C<br />12.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 17 h / |Reflux<br />13.1: sodium tetrahydroborate / N,N-dimethyl-formamide / 12 h / 80 °C / |Cooling with ice<br /> <br />
参考文献
Kawashima, Hidehisa; Kaneko, Yuki; Sakai, Masahiro; Kobayashi, Yuichi Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 272 - 278
