alpha-甲基-2-哌啶甲醇合成路线 （共 7 条）
反应条件
hydrogenchloride; thionyl chloride in 1,4-dioxane; chloroform
参考文献
Apodaca, Richard; Carruthers, Nicholas I.; Carson, John R.; Chai, Wenying; Kwok, Annette K.; Li, Xiaobing; Lovenberg, Timothy W.; Rudolph, Dale A.; Shah, Chandravadan R.
Patent: US2003/13733 A1, 2003 ;
反应条件
1: With lithium aluminium tetrahydride in diethyl ether
T=0°C; 16 h; Inert atmosphereCooling with iceReflux;
2: in diethyl ether
pH=3; Acidic aqueous solution;
参考文献
Morere, Alain; Menut, Chantal; Gunata, Yusuf Ziya; Agrebi, Abdelhamid
Patent: US2012/100274 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
platinum(IV) oxide in acetic acid
参考文献
Kuznetsov, S. G.; Libman, N. M.; Gorchakov, V. S.; Golikov, S. N.; Zatsepin, E. P.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 4 p. 253 - 258
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 4 p. 435 - 440
反应条件
1: 69 percent
2: 72.5 percent / PtO2 / acetic acid
View Scheme
参考文献
Kuznetsov, S. G.; Libman, N. M.; Gorchakov, V. S.; Golikov, S. N.; Zatsepin, E. P.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 4 p. 253 - 258
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 4 p. 435 - 440
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / 24 h / 60 °C
2.1: sodium carbonate / water / 4 h / 20 °C
3.1: lithium aluminium tetrahydride / diethyl ether / 16 h / 0 °C / Inert atmosphere; Cooling with ice; Reflux
3.2: pH 3 / Acidic aqueous solution
View Scheme
参考文献
Morere, Alain; Menut, Chantal; Gunata, Yusuf Ziya; Agrebi, Abdelhamid
Patent: US2012/100274 A1, 2012 ;
反应条件
1.1: sodium carbonate / water / 4 h / 20 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 16 h / 0 °C / Inert atmosphere; Cooling with ice; Reflux
2.2: pH 3 / Acidic aqueous solution
View Scheme
参考文献
Morere, Alain; Menut, Chantal; Gunata, Yusuf Ziya; Agrebi, Abdelhamid
Patent: US2012/100274 A1, 2012 ;
反应条件
Dess-Martin periodane in dichloromethane
Inert atmosphere;
参考文献
Morere, Alain; Menut, Chantal; Gunata, Yusuf Ziya; Agrebi, Abdelhamid
Patent: US2012/100274 A1, 2012 ;
Location in patent: Page/Page column 9-10 ;
