2-氯-3,4-二甲氧基苯甲醛合成路线 （共 28 条）
反应条件
1: 90 percent / Cl2 2: 66 percent / K2CO3 / dimethylformamide / 0.08 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 11 p. 2315 - 2325
反应条件
potassium carbonate in acetonitrile
参考文献
Rohm and Haas Company
Patent: US5866513 A1, 1999 ;
反应条件
sodium hydroxide in chloroform; water; acetonitrile
参考文献
Eisai Co., Ltd.
Patent: US5292521 A1, 1994 ;
反应条件
1: 2-chloro-1-iodo-3,4-dimethoxy-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=0°C; 1 h;
参考文献
Almeida, Maria; Boman, Arne; Lundstedt, Torbjrn
Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 5 p. 371 - 377
反应条件
potassium carbonate in N,N-dimethyl-formamide 0.0833333 h; Heating;
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
in N-methyl-acetamide; tetrachloromethane; ethanol; acetonitrile
反应条件
1.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / -78 °C / |Inert atmosphere 1.2: 1 h / -78 °C / |Inert atmosphere 2.1: zirconocene dichloride; lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0.33 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Organic Letters, , vol. 16, # 2 p. 390 - 393
反应条件
chloroform; 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane und Erhitzen des Reaktionsprodukts mit wss.Essigsaeure;
参考文献
Journal of the American Chemical Society, , vol. 77, p. 5314,5317
反应条件
1: acetic acid / 60 °C 2: hexamethylenetetramine; CHCl3 / und Erhitzen des Reaktionsprodukts mit wss.Essigsaeure View Scheme
参考文献
Journal of the American Chemical Society, , vol. 77, p. 5314,5317
反应条件
1.1: 72 percent / lead tetraacetate; iodine; AIBN / CCl4 / 2 h / Heating 2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C 2.2: 65 percent / tetrahydrofuran; hexane / 1 h / 0 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 45, # 5 p. 371 - 377
