2-氯-3,4-二甲氧基苯甲醛合成路线 （共 28 条）
反应条件
n-butyllithium; 1,2,2-trichloro-1,1,2-trichloro-ethane; N,N,N'-trimethyl-ethylenediamine 1.) THF, from -70 deg C to -30 deg C, 8 h, 2.) THF, RT, 3 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1586 - 1590
反应条件
methanol; sodium hydroxide durch anschliessendes Erwaermen mit Dimethylsulfat;
参考文献
Journal of Organic Chemistry, , vol. 7, p. 354,355
参考文献
Hornbaker; Burger
Journal of the American Chemical Society, 1955 , vol. 77, p. 5314,5317
反应条件
sodium acetate; acetic anhydride
参考文献
Kaiser; Burger
Journal of the American Chemical Society, 1957 , vol. 79, p. 4365,4369
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 2: 97 percent / 12N aq. HCl 3: 96 percent / dimethylsulfoxide / 1.25 h 4: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 2: 97 percent / 12N aq. HCl 3: 96 percent / dimethylsulfoxide / 1.25 h 4: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 5: 19 percent / 2.5 h / Heating 6: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 2: 97 percent / 12N aq. HCl 3: 96 percent / dimethylsulfoxide / 1.25 h 4: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 5: 19 percent / 2.5 h / Heating 6: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C 7: 95 percent / BBr3 / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
potassium permanganate in water T=75°C; 2.5 h;
参考文献
Almeida, Maria; Boman, Arne; Lundstedt, Torbjrn
Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 5 p. 371 - 377
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C 2: 97 percent / 12N aq. HCl 3: 96 percent / dimethylsulfoxide / 1.25 h 4: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 5: 19 percent / 2.5 h / Heating View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 95 percent / ammonium acetate / acetic acid / 3 h / Heating 2: 80 percent / LiAlH4, AlCl3 / tetrahydrofuran / 16 h / Ambient temperature 3: Me3SiI / CHCl3; tetrahydrothiophene 1,1-dioxide / 72 h / 50 °C View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
