4-(甲基硫代)-1H-吡唑并[3,4-d]嘧啶合成路线 (共 5 条)
反应条件
in N,N-dimethyl-formamide; toluene
T=0 - 25°C;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: EP1772454 A1, 2007 ;
Location in patent: Page/Page column 61 ;
EP 1772454 A1
参考文献
Amersham Pharmacia Biotech UK Limited
Patent: US6600028 B1, 2003 ;
反应条件
1: 98 percent / P2S5 / pyridine / Heating
2: 78 percent / 0.8N NaOH / 0.42 h / 20 °C
View Scheme
参考文献
Moukha-Chafiq; Taha; Lazrek; Pannecouque; Witvrouw; De Clercq; Barascut; Imbach
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1797 - 1810
反应条件
1: thiourea; ethanol
2: aq. NaOH solution
View Scheme
参考文献
Robins
Journal of the American Chemical Society, 1956 , vol. 78, p. 784,787
Journal of the American Chemical Society, 1957 , vol. 79, p. 6407,6413
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Moukha-Chafiq; Taha; Lazrek; Pannecouque; Witvrouw; De Clercq; Barascut; Imbach
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 10-11 p. 1797 - 1810