2,4,6,8-四氯喹唑啉合成路线 (共 2 条)
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate
Reflux;
参考文献
Smits, Rogier A.; Adami, Maristella; Istyastono, Enade P.; Zuiderveld, Obbe P.; Van Dam, Cindy M. E.; De Kanter, Frans J. J.; Jongejan, Aldo; Coruzzi, Gabriella; Leurs, Rob; De Esch, Iwan J. P.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 6 p. 2390 - 2400
反应条件
1: 1 h / 200 °C
2: POCl3; N,N-dimethylaniline / 16 h / Heating
View Scheme
参考文献
Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney II, Stephen L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2297 - 2300