1-(氯甲基)-1H-苯并三唑合成路线 （共 26 条）
反应条件
iodine; magnesium
1.) THF, reflux, 3 h; 2.) THF, room temp., 6 h; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Rachwal, Stanislaw; Caster, Kenneth C.; Mahni, Fatma; Law, Kam Wah; Rubio, Olga
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 781 - 790
反应条件
aluminum tri-bromide
T=20°C; 3 h;
参考文献
Katritzky, Alan R.; Gordeev, Mikhail F.; Greenhill, John V.; Steel, Peter J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 9 p. 1111 - 1118
反应条件
1: bromobenzene With magnesium in diethyl ether
Metallation;
2: 1-(chloromethyl)-1H-benzotriazole in tetrahydrofuran; diethyl ether
Substitution; 3 h; Heating;
参考文献
Katritzky, Alan R.; Abdel-Fattah, Ashraf A. A.; Tymoshenko, Dmytro O.; Belyakov, Sergei A.
Synthesis, 1999 , # SPEC. ISS. p. 1437 - 1440
反应条件
in tetrahydrofuran
1.) 0 deg C, 3 h; 2.) room temp., 1 h;
参考文献
Katritzky, Alan R.; Rachwal, Stanislaw; Caster, Kenneth C.; Mahni, Fatma; Law, Kam Wah; Rubio, Olga
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 781 - 790
参考文献
Burckhalter et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 3868
反应条件
1: NaI / acetone / 4 h / Ambient temperature
View Scheme
参考文献
Katritzky, Alan R.; Hughes, Craig V.; Rachwal, Stanislaw
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1579 - 1588
