hydrogenchloride in diethyl ether byproducts: LiCl, i-propanol; (N2); a soln. of B(O-i-Pr)3 cooled with a dry ice-acetone bath; CH3Li added slowly and stirred for 1 h; allowed to warm to room temp. with stirring for 3 h; cooled to 0°C; a soln. of HCl in ether added and stirred for 0.5 h; decanted; hydrolyzed with water; distd.; dried;
参考文献
Brown, Herbert C.; Cole, Thomas E.
Organometallics, 1985 , vol. 4, p. 816 - 821
1: 1-bromo-2-(methylthio)benzene With n-butyllithium in tetrahydrofuran; hexane T=-75°C; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=20°C; Cooling; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=20°C; Cooling with ice;
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP946508 B1, 2009 ;
Location in patent: Page/Page column 60 ;
